Between 1996 and 2003, Mercedes-Benz produced the Vito of the first generation.

As a more opulent and upmarket variant, the body style was also offered under the V-Klasse brand (the V-Klasse name was dropped for the second generation of the Vito). In November 2017, the eVito, an electric panel van variation utilising the W447 chassis, was released.

The EQV, with a more potent drivetrain and a larger battery than the eVito, was shown as a concept at the March 2019 Geneva Motor Show. It is an electric version of the V-Class that uses the same Vito W447 chassis.

This year, Mercedes-Benz Vans has introduced its refreshed medium-sized series with a new exterior and interior design. The series consists of the new EQV, V-Class and V-Class Marco Polo, the new eVito and Vito.